Natural Killer Cells

[Immunity] The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Researchers examined the impact of microbiota-specific T cells in anti-colorectal cancer immunity.

[Human Immunology] The authors reviewed the molecular mechanisms and the role of immune cells and responses involved in pulmonary hypertension development.

[Signal Transduction and Targeted Therapy] The authors showed that natural killer (NK)-derived exosomes from lean mice attenuated obesity-induced insulin resistance and inflammation in mice of type 2 diabetes, and that lean NK-derived exosomes enhanced insulin sensitivity and relieve inflammation in adipocytes and hepatocytes.

[Haematologica] PVRIG blockade significantly enhanced NK-cell killing of poliovirus receptor-related 2 (PVRL2)+, poliovirus receptorlo AML cell lines, and significantly increased NK-cell activation and degranulation in the context of patient primary AML blasts.

[PLoS Pathogens] Investigators compared vaccine responses in Phase I and II studies in humans utilizing various combinations of DNA/vector, vector/vector and DNA/protein HIV vaccines.

[PLoS One] Scientists revealed a lymphoid TBX-code and used it to identify an aberrant network around deregulated T-box gene TBX3 in Hodgkin lymphoma which promoted hallmark aberrations of this disease.