Natural Killer Cells

[PLoS One] Researchers described a simple and effective protocol to study the cytotoxic activity of primary human NK cells toward the 3D tumor spheroids.

[Science Advances] ECM proteins, collagen I, collagen III, and elastin, blocked natural killer (NK) cell cytotoxicity and promoted their chemokine/cytokine production. NK cell cytotoxicity against major histocompatibility complex class I (MHC-I)–deficient melanoma in the skin was markedly increased by blocking tumor collagen deposition.

[Journal of Translational Medicine] Researchers evaluated the functionality of mRNA-engineered dual-CAR NK-92 against tumor B cell lines and primary patient samples.

[Cancer Immunology Research] Scientists studied the consequences of pAg-stimulated γδ T cell interactions with Natural Killer cells and CD8+ T cells, major innate and adaptive effectors, respectively.

[Scientific Reports] Researchers investigated the epithelial cell response to B. pertussis infection in primary human airway epithelium differentiated at air–liquid interface.

[Cancer Immunology Research] Researchers tested the in vitro effect of different natural killer (NK)-cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and targeted either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.