neural cells

[Cell Stem Cell] Using direct conversion of Alzheimer’s disease patient fibroblasts into induced neurons, scientists generated an age-equivalent neuronal model.

[Scientific Reports] Transient overexpression of miR-138 in glioblastoma cells inhibited cell proliferation, cell cycle, migration, and wound healing capability.The authors unveiled that miR-138 negatively regulated the expression of CD44 by directly binding to the 3′ UTR of CD44.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that in mouse hippocampal neurons, dense core vesicles fusion was strongly and equally reduced in synaptotagmin-1 (Syt1)- or Syt7-deficient neurons, but combined Syt1/Syt7 deficiency did not reduce fusion further.

[Proceedings of the National Academy of Sciences of the United States of America] Proteomic changes occurred within five min of intracarotid arterial hyperosmolar mannitol (ICAHM) infusion and returned to baseline by 96 hours. Transcriptomic analyses following ICAHM blood–brain barrier disruption further supported an sterile inflammatory response.

[Scientific Reports] Motor function was analyzed by three behavioral tests. Engraftment of human amniotic fluid stem cell in organs were assessed by flow cytometry and RNA scope.

[Advanced Healthcare Materials] Researchers report an in vitro mild traumatic brain injury modeling system based on 3D cultured human iPSC derived neural progenitor cells to evaluate consequences of single and repetitive mild traumatic brain injury using a 3D printed mini weight‐drop impact device.