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Pulmonary Cell NewsProteomic changes occurred within five min of intracarotid arterial hyperosmolar mannitol (ICAHM) infusion and returned to baseline by 96 hours. Transcriptomic analyses following ICAHM blood–brain barrier disruption further supported an sterile inflammatory response.
[Proceedings of the National Academy of Sciences of the United States of America]
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Burks, S. R., Kersch, C. N., Witko, J. A., Pagel, M. A., Sundby, M., Muldoon, L. L., Neuwelt, E. A., & Frank, J. A. (2021). Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses. Proceedings of the National Academy of Sciences, 118(18). https://doi.org/10.1073/pnas.2021915118 Cite
