neural cells

[Journal of Neuroscience] Using patient-derived iPSC neurons expressing a tau aggregation biosensor, researchers developed a cell culture system that allowed continuous assessment of both induced tau aggregation and neuronal viability at single-cell resolution for periods of >1 week.

[Scientific Reports] Scientists investigated the mechanisms underlying the anti-inflammatory and anti-migratory functions of JQ1 and the genes targeted by JQ1 in lipopolysaccharide-activated human microglial clone 3 cells using RNA-sequencing.

[Nature Communications] The authors report, the astrocyte-derived secreted lipocalin Glial Lazarillo , a homolog of human Apolipoprotein D, and its neuronal receptor, the brain-specific short isoforms of Drosophila lipophorin receptor 1, cooperatively mediated neuron-glia lipid shuttling and support dendrite morphogenesis.

[Molecular Therapy] The unique ability of extracellular vesicles (EVs) to pass through the blood brain barrier further conferred them an important role in the bidirectional communication between the central nervous system and periphery, and application of EVs enabled the diagnosis, prognosis, and therapy of neuroinflammatory diseases in a minimally invasive manner.

[Scientific Reports] Investigators utilized a neonatal rat model of bronchopulmonary dysplasia to assess if hyperoxia stimulates lung release of circulating extracellular vesicles(EVs) and if these EVs induce lung and brain injury.

[Molecular Psychiatry] Induced pluripotent stem cells derived from individuals deficient in CDKL5 protein were used to generate neural cells. Proteomic and phosphoproteomic approaches revealed disruption of several pathways, including microtubule-based processes and cytoskeleton organization.