neural cells

[International Journal of Cardiology] For translation of our findings, investigators combined in vitro cytochemical, molecular and pharmacologic assays on human cardiac MSCs, from myocardial biopsies of healthy controls and arrhythmogenic cardiomyopathy (AC) patients, with the use of existing drugs to interfere with the predicted AC mechanisms.

[Journal of Molecular Neuroscience] After stimulation with Zeb2/Axin2-enriched BMSC exosomes, the spatial memory and nerve function of MCAO rats showed marked recovery. The number of neurons was increased in the subventricular zone, hippocampus, and cortex area, while the expression of nerve growth factors was upregulated.

[Cell Stem Cell] Around day 30, brain organoids attempted to assemble optic vesicles, which developed progressively as visible structures within 60 days. These optic vesicle-containing brain organoids constitute a developing optic vesicle’s cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progenitor cells, axon-like projections, and electrically active neuronal networks.

[Nature Cancer] Investigators identified chemical inhibitors for PUS7 and showed that these compounds prevented pseudouridine synthase 7 (PUS7)-mediated pseudouridine modification, suppressed tumorigenesis and extended the life span of tumor-bearing mice.

[Molecular Psychiatry] In vitro studies showed that an interaction between amyloid precursor protein (APP) and the iron-bound form of lactoferrin secreted from activated microglia diverted neuronal APP endocytosis from the canonical clathrin-dependent pathway to one requiring ADP ribosylation factor 6 trafficking.

[Neuropsychopharmacology] Scientists investigated the mechanisms underlying the aberrant activation of microglia elicited by Meth in the adult mouse brain. They found that binge Meth exposure caused microgliosis and disrupted risk assessment behavior both of which required astrocyte-to-microglia crosstalk.