neurons

[Cell Stem Cell] Using direct conversion of Alzheimer’s disease patient fibroblasts into induced neurons, scientists generated an age-equivalent neuronal model.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that in mouse hippocampal neurons, dense core vesicles fusion was strongly and equally reduced in synaptotagmin-1 (Syt1)- or Syt7-deficient neurons, but combined Syt1/Syt7 deficiency did not reduce fusion further.

[Scientific Reports] Motor function was analyzed by three behavioral tests. Engraftment of human amniotic fluid stem cell in organs were assessed by flow cytometry and RNA scope.

[Journal of Neuroscience] Using patient-derived iPSC neurons expressing a tau aggregation biosensor, researchers developed a cell culture system that allowed continuous assessment of both induced tau aggregation and neuronal viability at single-cell resolution for periods of >1 week.

[Nature Communications] The authors report, the astrocyte-derived secreted lipocalin Glial Lazarillo , a homolog of human Apolipoprotein D, and its neuronal receptor, the brain-specific short isoforms of Drosophila lipophorin receptor 1, cooperatively mediated neuron-glia lipid shuttling and support dendrite morphogenesis.

[Molecular Therapy] The unique ability of extracellular vesicles (EVs) to pass through the blood brain barrier further conferred them an important role in the bidirectional communication between the central nervous system and periphery, and application of EVs enabled the diagnosis, prognosis, and therapy of neuroinflammatory diseases in a minimally invasive manner.