neurons

[Biotechnology and Bioengineering] Scientists investigated whether Schwann cells could be involved in the disease pathogenesis, and developed a tissue-engineered 3D in vitro model that combined motor neurons cocultured with astrocytes.

[npj Parkinsons Disease] Using two chimeric mouse models, scientists demonstrated that the replacement of mutant LRRK2 with wild-type formed of the protein in T- and B-lymphocytes diminished LPS-mediated inflammation and rescued the substantia nigra pars compacta dopamine neuron loss in the mutant LRRK2 brain.

[eLife] Steady-state and stable isotope flux analyses demonstrated increased rates of glycolysis, acetyl-CoA production, acetylcholine levels and density of neuromuscular synaptic junction clusters with enhanced acetylcholine release.

[Cell Reports] Researchers reported a non-invasive all-optical strategy to induce stem cell differentiation in vitro and in vivo that activated individual target stem cells in situ by delivering a transient 100-ms irradiation of a tightly focused femtosecond laser to a submicron cytoplasmic region of primary adipose-derived stem cells.

[Scientific Reports] Researchers characterized the progression and the cellular mechanisms involved in α-synuclein pre-formed fibrils transfer from enteroendocrine cells to neuronal cells.

[Journal of Cellular and Molecular Medicine] The authors transplanted cells that were generated from hiPSCs into regionally specific spinal neural progenitor cells utilizing a novel accelerated differentiation protocol designed for clinical translation.