neutrophils

[Cancer Gene Therapy] The authors discuss the importance of oncolytic viruses-based combination therapies in optimizing antiviral and antitumor innate immune responses stimulated by virotherapy toward tumor eradication, and how these processes vary depending on the tumor and oncolytic viruses in question.

[Cell Reports] Researchers compared the immune profiles generated by KrasG12D-mutated mouse pancreatic ductal epithelial cells engineered genetically to express the Trp53R172H mutation with their p53 wild-type control.

[Acta Pharmacologica Sinica] Researchers found that ethyl ferulate significantly alleviated lipopolysaccharide-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines in murine lung tissues.

[Immunology] Understanding the mechanisms underpinning the effects of neutrophils on lymph node immune cells and adaptive immunity could facilitate the development of neutrophil-targeted therapies in inflammatory diseases.

[Nature Communications] Single-cell transcriptomics and multiparametric imaging applied to a mouse model of breast cancer reveals that the aggressive tumor niche was characterized by an expanded basal-like population, specialization of tumor subpopulations, and mixed-lineage tumor cells potentially serving as a transition state between luminal and basal phenotypes.

[Nature Immunology] The authors showed that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus undergo ferroptosis.