NF-κB

[Journal of Investigative Dermatology] Investigators confirmed that the rosacea-like skin inflammation induced by Cathelicidin LL37 was alleviated in aged mice and mice with progeria.

[Nature Communications] Researchers depicted an interplay of molecular, cellular, and tissue microenvironment alterations that increased BRCA1-associated breast cancer risk.

[Scientific Reports] Investigators investigated the role of lipid phosphate phosphatase 3 and lysophospholipid signaling in a well-defined model of pathologic aortic injury.

[Cell Death Discovery] IL-37 isoform D transgene amplified ST2+ immune cells, promoted M2 macrophage polarization and type 2 cytokine secretion in white adipose tissue that mediated beiging and inflammation resolution, thereby increasing energy expenditure, reducing obesity and insulin resistance in high-fat diet-fed mice.

[Cell Death Discovery] Researchers analyzed the expression of α7nAchR in human and mouse psoriatic skin tissue. In vivo, PNU-282987 or Methyllycaconitine, a specific agonist or antagonist of α7nAchR, were administered to imiquimod-induced psoriatic mouse models.

[Molecular Therapy] Researchers reported that FOSL1, a component of AP-1 transcription factor complexes, was a key player in regulating PMT. FOSL1 was predominantly expressed in the mesenchymal subtype, but not proneural subtype of glioblastoma stem cells.