organoids

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Investigators isolated primary alveolar type-2 cells (AEC2) from patient-derived lung tissues including those from patients with severe emphysema, using magnetic bead-based selection of cells expressing the AEC2 marker HTII-280.

[Critical Reviews in Oncology/Hematology] As methods to culture lung cancer organoids increase in sophistication, this model will undoubtedly stand its ground in the coming years in every aspect of cancer researches, especially with major advantages in the field of personalized medicine and tumor microenvironment researches.

[Clinical Cancer Research] Scientists tested if inhibition of DOT1L, an epigenetic regulator of normal tissue stem/progenitor populations, would target triple negative breast cancers stem cells.

[University of Washington Department of Bioengineering] University of Washington bioengineer Kelly Stevens, whose research focuses on mapping human organs and engineering artificial human tissues, has received an Allen Distinguished Investigator Award to support her work to map and understand how human livers develop.

[Scientific Reports] Researchers established motor nerve organoids from human PSCs with properties similar to those of neuromesodermal progenitors, a population of progenitor cells that comprise the caudal spinal cord.

[Cell Death Discovery] Using hiPSC-derived retinal organoids, researchers identified the time-dependent role of mammalian target of rapamycin complex 1 (mTORC1) in retinal development, specifically in retinal ganglion cell differentiation and the retinal lamination process, during the early stages of retinal organoid development.