organoids

[Stem Cell Reports] Scientists established a novel in vitro pulmonary fibrosis model using alveolar organoids consisting of human pluripotent stem cell-derived alveolar epithelial cells and primary human lung fibroblasts.

[Journal For Immunotherapy of Cancer] Autologous tumor organoids were stimulated with T cells from the patients’ peripheral blood for two weeks to generate the organoid-primed T cells.

[Stem Cell Research & Therapy] Researchers demonstrated the generation of more advanced in vitro multiocular organoids from human iPSCs. In the 2D culture, self-formed multizone ocular progenitor cells spanned the neuroectoderm, surface ectoderm, neural crest, and retinal pigment epithelium, mimicking early stages of eye development.

[Nature Communications] Scientists highlight emerging technologies and infection models that recently promoted opportunities in cellular microbiology.

[Signal Transduction and Targeted Therapy] Fusobacterium nucleatum induces different immune responses in colorectal cancer (CRC) with different microsatellite-instability statuses. Scientists investigated the effect of F. nucleatum on anti-PD-L1 therapy in CRC.

[Communications Biology] Researchers performed whole-genome sequencing on clonally expanded single liver stem cells cultured as intrahepatic cholangiocyte organoids from patients with alcoholic cirrhosis, non-alcoholic steatohepatitis, and primary sclerosing cholangitis.