Multiocular Organoids from Human Induced Pluripotent Stem Cells Displayed Retinal, Corneal, and Retinal Pigment Epithelium Lineages

Researchers demonstrated the generation of more advanced in vitro multiocular organoids from human iPSCs. In the 2D culture, self-formed multizone ocular progenitor cells spanned the neuroectoderm, surface ectoderm, neural crest, and retinal pigment epithelium, mimicking early stages of eye development.