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ovarian cancer

Development and Validation for Prognostic Nomogram of Epithelial Ovarian Cancer Recurrence Based on Circulating Tumor Cells and Epithelial–Mesenchymal Transition

[Scientific Reports] Scientists used CanPatrol circulating tumor cells (CTC)-enrichment technique to detect CTCs from blood samples and classify subpopulations into epithelial, mesenchymal, and hybrids.

Anti-Cancer Effects of Polyphenol-Rich Sugarcane Extract

[PLoS One] Investigators showed that polyphenol-rich sugarcane extract exerted anti-cancer properties on a range of cancer cells including human and mouse colon cancer cells lines; human lung cancer, human ovarian cancer, pro-monocytic human leukemia and mouse melanoma cell lines

Personalized Cancer Vaccine Strategy Elicits Polyfunctional T Cells and Demonstrates Clinical Benefits in Ovarian Cancer

[npj Vaccines] Scientists hypothesized that adding acetylsalicylic acid and low-dose interleukin-2 would increase the vaccine efficacy in a recurrent advanced ovarian cancer Phase I trial.

Pre-Clinical Small Molecule WEHI-7326 Overcomes Drug Resistance and Elicits Response in Patient-Derived Xenograft Models of Human Treatment-Refractory Tumors

[Cell Death & Disease] Investigators describe results with a new anti-cancer small molecule, WEHI-7326, which caused cell cycle arrest in G2/M, cell death in vitro, and displayed efficacious anti-tumor activity in vivo.

Synergistic Effects of Type I PRMT and PARP Inhibitors against Non-Small Cell Lung Cancer Cells

[Clinical Epigenetics] The combination of MS023, a type I protein arginine methyltransferases (PRMT) inhibitor, and the PARP inhibitor BMN-673 demonstrated strong synergistic interaction at low nanomolar concentrations in methylthioadenosine phosphorylase-negative NSCLC cell lines A549, SK-LU-1 and HCC4006.

Endothelin-1 Drives Invadopodia and Interaction with Mesothelial Cells through ILK

[Cell Reports] Researchers report that β-arrestin1 (β-arr1) links the integrin-linked kinase (ILK)/βPIX complex to activate Rac3 GTPase, acting as a central node in the adhesion-based extracellular matrix sensing and degradation.

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