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Pulmonary Cell NewsInvestigators describe results with a new anti-cancer small molecule, WEHI-7326, which caused cell cycle arrest in G2/M, cell death in vitro, and displayed efficacious anti-tumor activity in vivo.
[Cell Death & Disease]
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Grohmann, C., Walker, F., Devlin, M., Luo, M.-X., Chüeh, A. C., Doherty, J., Vaillant, F., Ho, G.-Y., Wakefield, M. J., Weeden, C. E., Kamili, A., Murray, J., Po’uha, S. T., Weinstock, J., Kane, S. R., Faux, M. C., Broekhuizen, E., Zheng, Y., Shield-Artin, K., … Lessene, G. (2021). Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors. Cell Death & Disease, 12(3), 1–18. https://doi.org/10.1038/s41419-020-03269-0 Cite
