ovarian cancer

[JCI Insight] Investigators performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy.

[Journal of the American Chemical Society] Through structure-activity relationship studies focused on the actin-binding tail region of MycB, scientists identified a potent truncated derivative that inhibits polymerization of G-actin and severs F-actin by binding to actin’s barbed end cleft.

[Science Translational Medicine] Researchers improved the specificity and persistent antitumor activity of therapeutic T cells with synthetic Notch CAR circuits.

[Acta Pharmacologica Sinica] Researchers investigated the effect of triptolide on the migration and invasion of non-small cell lung cancer cell lines.

[British Journal of Pharmacology] To unveil dregamine 5‐bromo‐pyridin‐2‐ylhydrazone (BBIT20), antitumor activity and underlying molecular mechanism of action, 2D and 3D cell cultures, patient-derived cell lines and xenograft mouse models were used.

[International Journal of Pharmaceutics] The toxicity of Gemini-Cur on HT-29 and HCT116 was studied through MTT, uptake kinetics, fluorescence microscopy, annexin V/FITC, and cell cycle assays.