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Pulmonary Cell NewsResearchers improved the specificity and persistent antitumor activity of therapeutic T cells with synthetic Notch CAR circuits.
[Science Translational Medicine]
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Hyrenius-Wittsten, A., Su, Y., Park, M., Garcia, J. M., Alavi, J., Perry, N., Montgomery, G., Liu, B., & Roybal, K. T. (2021). SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Science Translational Medicine, 13(591). https://doi.org/10.1126/scitranslmed.abd8836 Cite
