p53

[Science] Scientists characterized leader cells emerging from epithelial monolayers in cell culture and found that they activated the stress sensor p53, which was sufficient to initiate leader cell behavior.

[Scientific Reports] Scientists explored clinical factors in 332 advanced NSCLC who received EGFR TKI and molecular characteristics through 65 whole exome sequencing of various EGFR TKI responses including; de novo, intermediate response and long-term response.

[Signal Transduction and Targeted Therapy] Researchers demonstrated that intracellular cytokine-like protein 1 (CYTL1) played a key role in preventing the robust glycolytic switching characteristics of breast cancer.

[Nature Communications] The authors developed and optimized a CXCR4-targeted mRNA nanoparticle platform to effectively induce p53 expression in hepatocellular carcinoma models.

[Cell Death & Disease] PTBP3 knockdown in colorectal cancer cell lines restricted colorectal cancer proliferative capacities in vitro and in vivo.

[Cancer Cell] Investigators showed that, upon irradiation, interleukin-1α (IL-1α) not only polarized cancer-associated fibroblasts (CAFs) toward the inflammatory phenotype but also triggered oxidative DNA damage, thereby predisposing inflammatory CAFs to p53-mediated therapy-induced senescence, which in turn resulted in chemoradiotherapy resistance and disease progression.