pancreatic cells

[Basic & Clinical Pharmacology & Toxicology] MLKL inhibitor NSA attenuated the killing effect of IMB5036 on pancreatic cancer cells. IMB5036 stimulated translocation of MLKL and p-MLKL from cytoplasm to cell membrane.

[Endocrine] Regeneration proceedings for pancreatic β cells are promising and could improve β-cell proliferation capacity and contribute to the conservation of mature β-cell phenotypic characteristics.

[Cell Reports] Investigators demonstrated that Tentonin 3/TMEM150C, a mechanosensitive channel, contributes to glucose-stimulated insulin secretion by mediating cation influx.

[Journal of Physiology] Using a comprehensive combination of genetically modified fish, electrophysiology, and gene expression analysis, scientists demonstrated that zebra fish cardiac myocytes and vascular smooth muscle expressed functional ATP-sensitive potassium channels channels of similar subunit composition, structure, and metabolic sensitivity to their mammalian counterparts.

[Cancer Science] Investigators ectopically expressed α1,4-N-acetylglucosaminyltransferase (α4GnT), the α1,4-linked N-acetylglucosamine biosynthetic enzyme, together with MUC6 in the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, neither of which expressed α4GnT and MUC6.

[Biomedicine & Pharmacotherapy] The authors isolated pancreatic islets from adult male Wistar rats and identified pancreatic β-cells by the cell size, capacitance and membrane potential.