regulatory T cells

[Journal of Immunology] Scientists examined the cellular and molecular elements that promote CD8-to-CD4 lineage conversion and the development of CI-Treg cells in mice.

[Cell Host & Microbe] Researchers identified gut bacteria that synthesized isoalloLCA from 3-oxolithocholic acid and uncovered a gene cluster responsible for the conversion in members of the abundant human gut bacterial phylum Bacteroidetes.

[iScience] Utilising an in vitro migration assay, regulatory T cells from patients with psoriatic arthritis treated with conventional therapy paradoxically boosted CCR6+ effector T cell migration towards CCL20.

[Leukemia] The increased stemness of acute myeloid leukemia (AML) cells promoted by Tregs was verified in vitro and in vivo, and researchers found that blocking the interaction between Tregs and AML cells may be a new approach to target leukemia stem cells in AML treatment.

[Science Translational Medicine] Investigators found that antiangiogenic treatment facilitated non–small cell lung cancer tumor infiltration by PD-1+ regulatory T cells, which were more efficiently targeted by the PD-1 antibody than CD8+ T cells.

[Nature Communications] The authors utilized an engineered microbial organism with a six-letter semi-synthetic DNA code to generate a library of site-specific, click chemistry compatible amino acid substitutions in the human cytokine IL-2.