regulatory T cells

[Scientific Reports] Researchers investigated the effects of reducing the dose of posttransplantation cyclophosphamide (PTCy) followed by α-galactosylceramide, a ligand of iNKT cells, on the reciprocal balance between graft-versus-host disease (GVHD) and the graft-versus-leukemia (GVL) effect.

[Science Translational Medicine] Investigators demonstrated that mRNA delivery by polymeric nanoparticles could effectively induce expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in Pten-mutated melanoma cells and Pten-null prostate cancer cells, which in turn induced autophagy and triggered cell death–associated immune activation via release of damage-associated molecular patterns.

[EMBO Molecular Medicine] Scientists investigated this topic in an in vitro model using primary human T cells and in an immuno-nutritional intervention study enrolling healthy volunteers.

[Scientific Reports] The authors analyzed the profiling of immune cells in the peripheral blood of steroid-sensitive nephrotic syndrome patients and steroid-resistant nephrotic syndrome patients before and after standard steroid treatment to clarify the immunological mechanism of nephrotic syndrome patients.

[Cell] Researchers found that the polyclonal Treg cell repertoire is pre-enriched to recognize antigens presented by tumor-associated conventional dendritic cells.

[Environmental Research] The authors investigated the associations between gestational mercury exposure and frequency of cord blood T cells as well as placental gene expression.