Expansion of Tumor-Associated Treg Cells upon Disruption of a CTLA-4-Dependent Feedback Loop

By
Justin.choi
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0
301
Researchers found that the polyclonal Treg cell repertoire is pre-enriched to recognize antigens presented by tumor-associated conventional dendritic cells.
[Cell]
Marangoni, F., Zhakyp, A., Corsini, M., Geels, S. N., Carrizosa, E., Thelen, M., Mani, V., Prüßmann, J. N., Warner, R. D., Ozga, A. J., Pilato, M. D., Othy, S., & Mempel, T. R. (2021). Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.05.027 Cite
AbstractGraphical Abstract