regulatory T cells

[Molecular Therapy-Oncolytics] The authors reported a new strategy of blocking the CD7 antigen on the T cell surface with a recombinant anti-CD7 antibody to obtain a sufficient amount of CD7-targeting CAR-T cells for T cell acute lymphoblastic leukemia treatment.

[Hepatology] Scientists analyzed the immune landscapes of hypoxia-low and -high tumor regions using cytometry by time-of-flight, immunohistochemistry and transcriptomic analyses.

[Mucosal Immunology] Scientists reported specifically elevated expression of IL-36α, and not IL-36β or IL-36γ in the serum of newly diagnosed, treatment naïve, pediatric inflammatory bowel diseases patients and identify T cells as primary cellular mediators of IL-36 responses in the inflamed gut.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated that citrulline administration was more efficient than arginine in increasing arginine plasma levels and restoring T cell mitochondrial function and proliferation while reducing sepsis-induced T regulatory cells and myeloid-derived suppressor cells expansion.

[Nature Communications] Researchers demonstrated how direct and indirect contact with allogenic MSCs improves regulatory T cells' (Tregs) potential for accumulation of immunosuppressive adenosine and suppression of conventional T cell proliferation, making them more potent therapeutic tools.

[Leukemia] In co-cultures from 28 different chronic lymphocytic leukemia patients, the authors detected an expansion of T-follicular helper cells based on PD-1, BCL6, and ICOS expression, with increased IL-21 and downmodulated CD40L surface expression.