reporter assay

[Journal of Hematology & Oncology] Researchers highlight that lncROPM and its target PLA2G16 played crucial roles in sustaining breast CSC (BCSC) properties and might serve as a biomarker for BCSCs or other cancer stem cells.

[Cancer Cell International] The effects of conditioned media from oral squamous cell carcinoma cells on the angiogenic activities of endothelial cells were analyzed using a tube formation assay.

[Journal of Biochemical and Molecular Toxicology] Mouse and cell ALI models were constructed by lipopolysaccharide (LPS). NEAT1 knockdown efficiently attenuated LPS-induced ALI and reduced LPS-induced elevation of cytokines both in vitro and in vivo

[Molecular Medicine Reports] hsa_circ_105039 was underexpressed in the heart tissue of patients with congenital heart disease. Investigators found that hsa_circ_105039 overexpression promoted cell differentiation, viability and migration; whereas apoptosis was simultaneously repressed.

[Cell Death & Disease] Researchers confirmed the downregulation of miR-193b-3p in psoriasis patients, psoriasis-like inflammatory cellular models, and an imiquimod-induced mouse model.

[Cell Death & Disease] The authors suggest that circUBE2J2 may have acted as a competing endogenous RNA to regulate KLF7 expression through sponging miR-370-5P and played a regulatory functions in hepatocellular carcinoma.