SARS-CoV-2

[Scientific Reports] Scientists report that antibodies that displayed high levels of cross-reactivity with the SARS-CoV-2 spike, were incapable of neutralizing pseudoviruses expressing SARS-CoV-2 spike proteins and were unlikely to mediate ADE via FcγRII receptor engagement.

[Clinical Journal of the American Society of Nephrology] Using ex vivo cell models, investigators analyzed SARS-Cov2 interactions with kidney tubular cells and assessed direct tubular injury. These models comprised primary human kidney epithelial cells and more quiescent three-dimensional kidney spheroids.

[Cell Reports] Scientists investigated SARS-CoV-2 spike-specific memory B cells and their dependence on CD4+ T cell help in different settings of COVID-19.

[Nature Communications] Scientists developed a trimeric form of the receptor binding domain and showed that it induces a potent neutralizing antibody response against live virus with diverse effector functions and provided protection against SARS-CoV-2 challenge in mice and rhesus macaques.

[Signal Transduction and Targeted Therapy] Scientists review the current knowledge and crucial information about how SARS-CoV-2 attaches on the surface of host cells through a variety of receptors, such as ACE2, neuropilin-1, AXL, and antibody–FcγR complexes.

[Nature Reviews Immunology] The authors review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies.