schizophrenia

[Translational Psychiatry] Scientists found that disruption of glyoxalase I , the gene encoding a major catabolic enzyme scavenging the carbonyl group, increased vulnerability to external carbonyl stress, leading to abnormal phenotypes in hiPSCs.

[Translational Psychiatry] The apoptotic loss of dendritic spines would be aggravated by microglia activation through a recently described signaling system from complement abnormalities and proteins of the MHC, thus implicating the immune system in schizophrenia.

[Therapeutic Solutions International, Inc. (Cision US, Inc.)] Therapeutic Solutions International, Inc. and its subsidiary Campbell Neurosciences announced new data covered by its previously filed patents supporting the use of mesenchymal based stem cell therapy for schizophrenia.

[Mirage News] A research team from the Duke Center for Genomic and Computational Biology have teamed up with scientists at UNC-Chapel Hill and Flora Vaccarino at Yale University to narrow down areas of the genome previously marked relevant to schizophrenia risk.

[Translational Psychiatry] Inhibiting the excessive noradrenaline release by treatment with vitamin B6 supplementation into the brain and α2A adrenoreceptor agonist guanfacine (GFC) suppressed the increased NA metabolism and ameliorated the behavioral deficits.

[Brain] Researchers investigated whether the neuroimmune dysregulation vascular phenotype was intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome.