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Pulmonary Cell NewsScientists found that disruption of glyoxalase I , the gene encoding a major catabolic enzyme scavenging the carbonyl group, increased vulnerability to external carbonyl stress, leading to abnormal phenotypes in hiPSCs.
[Translational Psychiatry]
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Hara, T., Toyoshima, M., Hisano, Y., Balan, S., Iwayama, Y., Aono, H., Futamura, Y., Osada, H., Owada, Y., & Yoshikawa, T. (2021). Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons. Translational Psychiatry, 11(1), 1–12. https://doi.org/10.1038/s41398-021-01392-w Cite
