survivin

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that except for SP1, the other tethering partners of ERβ (Fos, Jun, Fra1) were down-regulated in TNBC, meaning that the tumor-suppressive functions of ERβ were severely compromised.

[Cell] Investigators characterized the proteogenomic landscape of lung squamous cell carcinoma (LSCC), providing a deeper exposition of LSCC biology with potential therapeutic implications.

[Scientific Reports] Scientists investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.

[Cell Death & Disease] Investigators exploited an antibody-based proteomic technology, i.e. the Reverse-Phase Protein microArrays, to measure key antigens and activated signaling in extracellular vesicles isolated from sera of prostate cancer patients.

[Experimental Cell Research] Reserachers investigated the effect of a cytidine deaminase inhibitor - Zebularine (Zeb) on anticancer activity of Gem in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.

[Nature Communications] The authors characterized the cellular and molecular heterogeneity within and across patients and delineate the dynamic evolution of tumor and immune cell compartments at single cell resolution in longitudinal specimens from ibrutinib-sensitive patients and non-responders.