Reserachers investigated the effect of a cytidine deaminase inhibitor – Zebularine (Zeb) on anticancer activity of Gem in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.
[Experimental Cell Research]
7753456 {7753456:9DJJDIZ8} apa 50 1 162885 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/ %7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-0a68503d9e5ff61d47205a84348525e0%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229DJJDIZ8%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22parsedDate%22%3A%222021-05-25%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EIn%20vitro%20assessment%20of%20a%20synergistic%20combination%20of%20Gemcitabine%20and%20Zebularine%20in%20pancreatic%20cancer%20cells.%20%282021%29.%20%3Ci%3EExperimental%20Cell%20Research%3C%5C%2Fi%3E%2C%20112660.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.yexcr.2021.112660%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.yexcr.2021.112660%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D9DJJDIZ8%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22In%20vitro%20assessment%20of%20a%20synergistic%20combination%20of%20Gemcitabine%20and%20Zebularine%20in%20pancreatic%20cancer%20cells%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22Pancreatic%20ductal%20adenocarcinoma%20%28PDAC%29%20is%20one%20of%20the%20deadliest%20cancers%20with%20an%20extremely%20poor%20prognosis.%20Gemcitabine%20%28Gem%29%20is%20still%20the%20mainstay%20drug%5Cu2026%22%2C%22date%22%3A%222021%5C%2F05%5C%2F25%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.yexcr.2021.112660%22%2C%22ISSN%22%3A%220014-4827%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fabs%5C%2Fpii%5C%2FS0014482721001920%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%223XSKJF5U%22%5D%2C%22dateModified%22%3A%222021-06-01T17%3A53%3A09Z%22%7D%7D%5D%7DIn vitro assessment of a synergistic combination of Gemcitabine and Zebularine in pancreatic cancer cells. (2021).
Experimental Cell Research, 112660.
https://doi.org/10.1016/j.yexcr.2021.112660 Cite 
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