TGFβ

[British Journal of Cancer] The authors identified homeobox B9 (HOXB9) as a critical regulator of metastatic metastatic prostate CSCs behavior.

[Thoracic Cancer] Researchers found that the SET domain containing 1A (SETD1A), the enzyme for methylation of histone 3 lysine 4, was elevated in lung cancer tissue compared to normal lung tissue.

[Nature Reviews Immunology] The full scope of these immune changes remains unclear but is likely to involve multiple components, such as immune cells, the extracellular matrix, endothelial and epithelial cells and a myriad of chemokines and cytokines, including transforming growth factor-β.

[Nature Reviews Immunology] The authors discuss the emerging understanding of RT-induced immune effects with particular focus on the lungs and gut and the potential immune crosstalk that occurs between these tissues.

[Scientific Reports] Investigators demonstrated that, in an in vitro setting, MAPC cells increase Treg frequencies by promoting Treg proliferation and CD4+ T cell differentiation into Tregs.

[Nature] Scientists used single-cell epigenomic analysis of hearts dynamically exposed to bromodomain and extra-terminal domain inhibitors to reveal a reversible transcriptional switch that underlied the activation of fibroblasts.