TNF-α

[Tissue Barriers] Scientists studied the effect of adipose-derived MSCs on obesity-induced multi-organ injuries in a diet-induced obese mouse model.

[Cell Death & Disease] Scientists identified calcium-regulated heat-stable protein 1 (CARHSP1) as a critical driver for radioresistance utilizing genome-wide CRISPR activation screening.

[Scientific Reports] Expression and localization of Parkinson’s disease 7 were determined in the colon biopsies of children with inflammatory bowel disease, in the colon of dextran sodium sulphate treated mice, and in HT-29 colonic epithelial cells.

[Acta Pharmacologica Sinica] Diosmetin administration significantly decreased disease activity index score and ameliorated microscopic colon tissue damage, increased the expression of tight junction proteins, and reduced the secretion of proinflammatory cytokines IL-1β, IL-6, TNF-α, and Cox-2 in colon tissue.

[Cell Biology and Toxicology] Scientists examined the effects and mechanisms of action of vitamin D3 on the expression of intercellular adhesion molecule-1 in vitro and in vivo with or without tumor necrosis factor α treatment.

[Cell Reports] Using a murine chronic myeloid leukemia (CML) model, investigators examined leukemia-induced alterations in mesenchymal cell populations and showed that 6C3+ stromal progenitors expanded in CML bone marrow and exhibited increased leukemia stem cells but reduced HSC supportive capacity.