Diosmetin Has Therapeutic Efficacy in Colitis Regulating Gut Microbiota, Inflammation, and Oxidative Stress via the Circ-Sirt1/Sirt1 Axis

Diosmetin administration significantly decreased disease activity index score and ameliorated microscopic colon tissue damage, increased the expression of tight junction proteins, and reduced the secretion of proinflammatory cytokines IL-1β, IL-6, TNF-α, and Cox-2 in colon tissue.