TNF-α-Induced Alterations in Stromal Progenitors Enhance Leukemic Stem Cell Growth via CXCR2 Signaling

Using a murine chronic myeloid leukemia (CML) model, investigators examined leukemia-induced alterations in mesenchymal cell populations and showed that 6C3+ stromal progenitors expanded in CML bone marrow and exhibited increased leukemia stem cells but reduced HSC supportive capacity.