TNF-α

[Cell Death Discovery] Investigators verified that microRNA-326 (miR-326) repressed the gene expression of immune checkpoint molecules PD-L1 and B7-H3 in lung adenocarcinoma (LUAD). They detected that the expression of miR-326 in LUAD tissue was negatively correlated with PD-L1/B7-H3.

[Scientific Reports] Investigators showed that genetic deletion of MAP4K4 or pharmacological inhibition of its encoded kinase, HGK, inhibited metastatic prostate cancer cells migration and clonogenic properties.

[Science Advances] Investigators identified that tumor necrosis factor receptor-associated factor 2 knockdown/knockout in multiple myeloma cells mediated immunomodulatory drug resistance via activation of noncanonical nuclear factor κB and extracellular signal–regulated kinase (ERK) signaling.

[Nature Biomedical Engineering] The authors showed that MSCs singly coated with a soft conformal gel presenting defined chemomechanical cues promoted matrix remodeling by secreting soluble interstitial collagenases in response to the presence of tumour necrosis factor alpha.

[Cell Death & Disease] Researchers analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.

[Scientific Reports] Scientists investigated the effect of extracellular vesicles derived from human umbilical cord-MSC on the clinical score and inflammatory/anti-inflammatory cytokines on the EAE mouse model.