tuberculosis

[npj Biofilms and Microbiomes] Researchers adapted a three-dimensional Rotary Cell Culture System to model M. bovis BCG biofilm growth in low-shear detergent-free liquid suspension.

[Nature Communications] Investigators generated monoclonal antibodies from memory B cells of one patient to investigate the B cell responses during active infection.

[Immunity] Researchers developed a coordinated system of chronic virus and Mycobacterium tuberculosis (Mtb) infection that induced central clinical manifestations of coinfection, including increased Mtb burden, extra-pulmonary dissemination, and heightened mortality.

[Experimental and Molecular Medicine] Researchers explored the pathogenic significance of histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) and evaluated the therapeutic effects of HRF/TCTP blockade in rheumatoid arthritis (RA). HRF/TCTP transgenic and knockdown mice with collagen-induced arthritis were used to determine the experimental phenotypes of RA.

[iScience] Forcing NLRC5 expression promoted Vγ9Vδ2 T cell-mediated killing of tumor cells in a BTN3A-dependent manner.

[Cell Reports] Scientists determined whether HIV infection of latent tuberculosis-infected subjects compromised the balanced Mycobacterium tuberculosis-specific T helper 17 response of recognized importance in anti-TB immunity.