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[Oncogene] Scientists uncovered that OTU deubiquitinase 1 (OTUD1) plays an important role in orchestrating cisplatin chemosensitivity of NSCLC.

[Communications Biology] Molecular and cellular experiments demonstrated that CAPRIN1 regulates the m6A modification of RIG-I RNA through direct interaction with METTL3, further influencing downstream interferon-associated gene networks and modulating Mycobacterium tuberculosis infection.

[Stem Cell Reports] Scientists delineated the state-of-the-art of muscle models by performing a large-scale analysis of transcriptome datasets, covering over 400 samples across 39 studies, including bulk and single-cell RNA sequencing of 2D and 3D models and their in vivo counterparts.

[Circulation Research] Researchers investigated whether and how cardiomyocyte NO-sensitive soluble guanylyl cyclase (GC1) mediates female-specific, adaptive right ventricular pressure-overload remodeling.

[Signal Transduction and Targeted Therapy] Scientists showed that sorafenib disrupts mitochondrial function by impairing the assembly of electron transport chain supercomplexes, thereby forcing cells to shift their metabolism toward glucose as the dominant energy source.

[Cell Stem Cell] Scientists performed single-cell RNA sequencing to analyze hematopoietic stem and progenitor cells and erythroid cells in a mouse model of high-altitude polycythemia mimicking long-term high-altitude hypoxia exposure.