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[Signal Transduction and Targeted Therapy] Scientists showed that sorafenib disrupts mitochondrial function by impairing the assembly of electron transport chain supercomplexes, thereby forcing cells to shift their metabolism toward glucose as the dominant energy source.

[Cell Stem Cell] Scientists performed single-cell RNA sequencing to analyze hematopoietic stem and progenitor cells and erythroid cells in a mouse model of high-altitude polycythemia mimicking long-term high-altitude hypoxia exposure.

[Autophagy] The authors showed that buddleoside treatment alleviated hepatic steatosis, insulin resistance, inflammation, and fibrosis in mice fed a high-fat and high-cholesterol diet.

[Blood] By examining the effects of hyperhomocysteinemi (HHcy) on a panel of G-protein coupled receptors (GPCRs) involved in platelet aggregation, investigators found that hyperhomocysteinemia (HHcy) systematically modulated biased GPCR signaling.

[Cell Stem Cell] Using single-cell transcriptomics combined with lineage tracing of proliferating progenitors, investigators examined mouse lung regeneration after influenza injury, demonstrating an asynchronously phased response across different cellular compartments.

[StemCyte, Inc.] StemCyte Inc. announced that the US FDA has approved the Biologics License Application for its HPC, Cord Blood product REGENECYTE™, a vital cord blood stem cell therapy for transplantation in patients with blood and immune system disorders.