Publication

[Environmental Toxicology] CCK-8, colony, and tumorsphere formation assay were used to evaluate cancer cell viability and stemness, respectively. Western blotting was used to detect the protein expression. Tumor xenograft experiments were employed to examine the tumorigenicity of colorectal cancer cells in nude mice.

[Pharmacological Research] Scientists demonstrated that circulating tumor-endothelial cells boost lung metastasis and angiogenesis. FACS and immunohistochemically analyses revealed a significant enrichment of Ly6G+/F4/80+/CD11b+ cells and Ly6G+/F4/80-/CD11b+ in the lung and in the spleen, while Ly6G+/F4/80-/CD11b+ in the bone marrow, indicating the occurrence of a systemic and local immune suppression.

[Physiological Genomics] Researchers demonstrated an efficient robust method to differentiate iPSCs into functional endothelial cells (ECs), and for the first time provide a comprehensive protein expression profile of iPSC lines into nontissue-specific pan vascul, which indicates their similarities with a widely used immortalized HUVECs.

[Heliyon] Researchers found an increase of RUNX family transcription factor 2 (RUNX2) expression and a decrease of YTHDC2 expression during the process of BMSCs osteogenic differentiation.

[Materials Today Bio] Strontium-doped mesoporous bioglass nanoparticles were synthesized through a modulated sol-gel method and Bi-lineage Inducible and Immunoregulatory Electrospun Fibers Scaffolds containing Sr-MBG were fabricated.

[Oral Diseases] Lipopolysaccharide and interleukin-10 (IL-10) were chosen to induce the polarization of macrophages. In vitro assessment included wound-healing assay, western blotting, and alizarin red staining after co-culture of the bone marrow-derived MSCs and induced macrophages.