Publication

[Cellular And Molecular Life Sciences] To assess neurofilament accumulations and study the impact on motor neurons (MNs), investigators compared MNs derived from induced pluripotent stem cells of patients carrying mutations in C9orf72, SOD1 and TARDBP genes, the three main ALS genetic causes.

[ACS Chemical Neuroscience] Menstrual stromal cell-derived dopamine-like neurons intoxicated with paraquat/maneb were used as a model system to elucidate the mechanism by which cannabidiol protects the neural cell from apoptosis in vitro.

[Food And Chemical Toxicology] Microglia BV-2 cells were exposed to various concentrations of alcohol for 3 or 12 h, imitating different stages of drunkenness after alcohol use, respectively, to the understanding of the action mechanisms of alcohol neurotoxicity.

[Bioelectronic Medicine] The combination of cells, bioink, and puromorphamine-releasing microspheres were used to mimic the in vivo environment and direct the differentiation of the neural progenitor cells into basal forebrain-resembling cholinergic neurons.

[Scientific Reports] Experiments inhuman-inducedd pluripotent stem cell-derived cortical and midbrain neurons showed AZD5438 mediated significant protective effects, preventing neuronal cell death, and collapse in the neurite and mitochondrial network associated with rotenone treatment.

[Scientific Reports] Scientists reported that the monomer:dimer ratio of phosphorylated p53 increased by 2.86-fold in the temporal lobes of Alzheimer's disease (AD) patients compared to age-matched controls, indicating that p53 oligomerization was compromised in AD.