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Human Immunology News
Outlining the Skin-Homing and Circulating CLA+NK Cells in Patients with Severe Atopic Dermatitis
[Scientific Reports] Scientists selected 44 atopic dermatitis (AD) patients and 27 non-AD volunteers for the study. The results showed increased frequencies of both CLA+CD56bright and CLA+CD56dim NK cell populations in the peripheral blood, mainly in severe AD patients.
Human Immunology News
Autologous Anti-GD2 CAR T Cells Efficiently Target Primary Human Glioblastoma
[npj Precision Oncology] Researchers generated pre-clinical investigations of autologous anti-GD2 CAR T cells tested against 2D and 3D models of glioblastoma primary cells.
Human Immunology News
Neuroinflammatory Disease Signatures in SPG11-Related Hereditary Spastic Paraplegia Patients
[Acta Neuropathologica] The authors performed a comprehensive immunological characterization of SPG11–hereditary spastic paraplegia, including examination of three human postmortem brain donations, immunophenotyping of patients’ peripheral blood cells and patient-specific induced pluripotent stem cell-derived microglia-like cells.
Cancer Stem Cell News
METTL16 Promotes Liver Cancer Stem Cell Self-Renewal via Controlling Ribosome Biogenesis and mRNA Translation
[Journal Of Hematology & Oncology] Liver-specific methyltransferase 16 (Mettl16 conditional KO mice were generated to assess its role in hepatocellular carcinoma pathogenesis and normal hepatogenesis.
Neural Cell News
Microglia Maintain Structural Integrity during Fetal Brain Morphogenesis
[Cell] Investigators uncovered a role for microglia in the maintenance of structural integrity at two fetal cortical boundaries.
Neural Cell News
Similar Brain Proteomic Signatures in Alzheimer’s Disease and Epilepsy
[Acta Neuropathologica] Scientists identified protein differences associated with epilepsy and Alzheimer’s disease using published proteomics datasets.