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Outlining the Skin-Homing and Circulating CLA+NK Cells in Patients with Severe Atopic Dermatitis

[Scientific Reports] Scientists selected 44 atopic dermatitis (AD) patients and 27 non-AD volunteers for the study. The results showed increased frequencies of both CLA+CD56bright and CLA+CD56dim NK cell populations in the peripheral blood, mainly in severe AD patients.

Autologous Anti-GD2 CAR T Cells Efficiently Target Primary Human Glioblastoma

[npj Precision Oncology] Researchers generated pre-clinical investigations of autologous anti-GD2 CAR T cells tested against 2D and 3D models of glioblastoma primary cells.

Neuroinflammatory Disease Signatures in SPG11-Related Hereditary Spastic Paraplegia Patients

[Acta Neuropathologica] The authors performed a comprehensive immunological characterization of SPG11–hereditary spastic paraplegia, including examination of three human postmortem brain donations, immunophenotyping of patients’ peripheral blood cells and patient-specific induced pluripotent stem cell-derived microglia-like cells.

METTL16 Promotes Liver Cancer Stem Cell Self-Renewal via Controlling Ribosome Biogenesis and mRNA Translation

[Journal Of Hematology & Oncology] Liver-specific methyltransferase 16 (Mettl16 conditional KO mice were generated to assess its role in hepatocellular carcinoma pathogenesis and normal hepatogenesis.

Microglia Maintain Structural Integrity during Fetal Brain Morphogenesis

[Cell] Investigators uncovered a role for microglia in the maintenance of structural integrity at two fetal cortical boundaries.

Similar Brain Proteomic Signatures in Alzheimer’s Disease and Epilepsy

[Acta Neuropathologica] Scientists identified protein differences associated with epilepsy and Alzheimer’s disease using published proteomics datasets.

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