Publication

[Small] In a murine model of colitis, Gal-IL10-extracellular vesicles alleviated inflammatory bowel disease symptoms including inflammatory responses and disrupted colonic barriers.

[Cell Death & Disease] Investigators found that the colorectal neoplasia differentially expressed (CRNDE)/heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) axis was notably elevated in colorectal cancer (CRC) and was strongly associated with poor prognosis of patients, while also significantly promoting CRC cell proliferation and metastasis both in vitro and in vivo.

[Microbiology Spectrum] An A. veronii strain (AS1) isolated from intestinal biopsies of a patient with inflammatory bowel disease was used for pathogenic mechanism investigation, and Escherichia coli K12 was used as a bacterial control. HT-29 cells were used as a model of human intestinal epithelium.

[International Immunopharmacology] Scientists identified TRIM59 as a critical and novel endogenous suppressor of kelch-like ECH-associated protein 1 (KEAP1) and also determined that TRIM59 was a KEAP1-interacting partner protein that catalyzes its ubiquitination and degradation in intestinal epithelial cells.

[Scientific Reports] Researchers characterized the DNA methylation profile of metastasis-competent circulating tumor cells in colorectal cancer (CRC). The DNA methylome of the human CRC-derived cell line CTC-MCC-41 was analyzed and compared with primary and metastatic CRC cells.

[Molecular Immunology] Investigators elucidated the mechanisms of mir-150–5p regulation on glucocorticoid resistance. An ulcerative colitis mouse model was used to evaluate changes in ulcerative colitis symptoms, inflammatory factors, and glucocorticoid resistance-related gene expression.