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Thioredoxin Facilitates Hepatocellular Carcinoma Stemness and Metastasis by Increasing BACH1 Stability to Activate the AKT/mTOR Pathway

[FASEB Journal] Functional studies showed that thioredoxin promoted hepatocellular carcinoma (HCC) stemness properties and facilitated HCC metastasis both in vitro and in vivo.

Dihydroartemisinin Inhibited Stem Cell-Like Properties and Enhanced Oxaliplatin Sensitivity of Colorectal Cancer via AKT/mTOR Signaling

[Drug Development Research] Researchers found that dihydroartemisinin (DHA) inhibited cell viability in HCT116 and SW620 cells. Moreover, DHA decreased cell clonogenicity, and improved oxaliplatin sensitivity.

MMP9 and TYROBP Affect the Survival of Circulating Tumor Cells in Clear Cell Renal Cell Carcinoma by Adapting to Tumor Immune Microenvironment

[Scientific Reports] Scientists searched for genes differentially expressed in circulating tumor cells (CTCs) by analyzing four CTCs and primary tumor gene expression datasets in the GEO database.

KIF15 Knockdown Inhibits the Development of Endometrial Cancer by Suppressing Epithelial-Mesenchymal Transition and Stemness through Wnt/β-Catenin Signaling

[Environmental Toxicology] Investigators detected the expression level of kinesin family member 15 (KIF15) in a microarray of endometrial cancer tissues by immunohistochemical staining, and analyzed the correlation between the expression level of KIF15 and the pathological characteristics of patients.

Human Memory B Cells Show Plasticity and Adopt Multiple Fates upon Recall Response to SARS-CoV-2

[Nature Immunology] Researchers showed that single severe acute respiratory syndrome coronavirus 2-specific memory B cell clones showed plasticity upon antigen rechallenge in previously exposed individuals.

The SARS-CoV-2 Papain-Like Protease Suppresses Type I Interferon Responses by Deubiquitinating STING

[Science Signaling] Scientists investigated the mechanism by which the SARS-CoV-2 papain-like protease (PLpro) antagonizes cellular antiviral response and revealed how SARS-CoV-2 PLpro inhibited type I interferon signaling through stimulator of interferon genes (STING) deubiquitination.

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