Review

[Trends In Parasitology] The authors review how regulatory T cellsmaintain the delicate balance between tolerance, immunity, and pathology in infection.

[Current Opinion In Structural Biology] Investigators highlight recent findings describing the dynamics and driving mechanisms for establishing 3D chromatin organization and discuss the role such organization has on gene regulation in early embryonic development.

[Seminars In Cancer Biology] The authors discuss potential mechanisms of transformation and review the current knowledge about cell of origin of NSCLC and SCLC. They also discuss treatment options for transformed SCLC, including chemotherapy, radiotherapy, TKIs, immunotherapy, and anti-angiogenic agents.

[Journal of Gastrointestinal Cancer] The authors review the biological significance of stemness and the results of potential colorectal CSC (CRCSC)-based targeted immunotherapies. They pointed out the barriers to targeting CRCSCs in vivo and highlight new strategies based on synthetic and biogenic nanocarriers for the development of future anti-CRCSC trials.

[CNS Neuroscience & Therapeutics] The authors compare brain tumor organoids (BTO) with common models including cell lines, tumor spheroids, and patient-derived xenografts. They conclude BTOs could be a reliable model to understand brain tumors and develop targeted therapies.

[Current Hematologic Malignancy Reports] Scientists review the clinical manifestations of GATA2 deficiency, characterization of the hematologic abnormalities and progression to myeloid malignancy, and current hematopoietic cell transplantation practices and outcomes.