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Plant-Derived Vesicle-Like Nanoparticles: A New Tool for Inflammatory Bowel Disease and Colitis-Associated Cancer Treatment

[Molecular Therapy] The authors summarize the latest advances in research on the sources and extraction methods, applications, and mechanisms in IBD and colitis-associated cancer therapy, overcoming drug resistance, safety, stability, and clinical application of plant-derived vesicle-like nanoparticles.

The Dark Side of Stemness – the Role of Hematopoietic Stem Cells in Development of Blood Malignancies

[Frontiers in Oncology] The authors review the evidence supporting the role of preleukemic HSCs in different types of blood cancers, as well as present the alternative models of malignant evolution.

Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells

[Stem Cell Reviews And Reports] Circulating tumor cells exhibit molecular diversity and stem-like and mesenchymal features, even when derived from primary tumor tissue from a single patient.

Epigenetic Reprogramming in the Transition from Pluripotency to Totipotency

[Journal of Cell Physiology] The authors highlight the recent findings in understanding the mechanisms of epigenetic remodeling during totipotency capture, including RNA splicing, DNA methylation, chromatin configuration, histone modifications, and nuclear organization.

Fighting Flu: Novel CD8+ T Cell Targets Are Required for Future Influenza Vaccines

[Clinical & Translational Immunology] The authors summarize many of the currently licensed influenza vaccines available across the world and current vaccines in clinical trials. They then briefly discuss the important role of CD8+ T cells during influenza infection and why future influenza vaccines should consider targeting CD8+ T cells.

Therapeutic Drug Monitoring of Imatinib – How Far Are We in the Leukemia Setting?

[Expert Review of Clinical Pharmacology] The authors summarize different antileukemic treatment indications for tyrosine kinase inhibitors with focus on imatinib and its pharmacokinetic/-dynamic properties.

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