Review

[Science Signaling] Investigators summarize their knowledge of the roles of these NF-κB pathways, which are activated in different intestinal cell types by specific ligands, and their cross-talk, in fueling aberrant intestinal inflammation.

[Nature Reviews Rheumatology] The registrational clinical trials and registry data of JAK inhibitors did not identify a difference in the risk of major adverse cardiovascular events, venous thromboembolism, malignancies or infections with a JAK inhibitor versus a biologic DMARD.

[International Journal Of Medical Sciences] The authors investigate the mechanisms underlying hair follicle (HF) development and regeneration. They study the structure, development, cycle, and cellular function of HFs.

[Nature Reviews Clinical Oncology] Scientists highlight advances in each antibody–drug conjugate component — the monoclonal antibody, payload, linker and conjugation chemistry — and provide more-detailed discussions on selected examples of emerging novel antibody–drug conjugates of each format, enabled by engineering of one or more of these components.

[mBio] Investigators cover the induced pluripotent stem cell-derived, brain-like endothelial cell model during host-pathogen interaction, highlighting the strengths and recent work on various pathogens known to interact with the blood-brain barrier.

[American Journal Of Physiology-Cell Physiology] The deepening knowledge of the chain of pathogenetic events involving endothelial cells, namely increased permeability, stiffening of the matrix, endothelial dysfunction, microvascular rarefaction, and tissue fibrosis, may provide a roadmap for therapeutic interventions deemed to curtail and reverse fibrosis.