Wnt/β-catenin

[Developmental Dynamics] The authors investigated the ability of renal organoids to undergo nephrogenesis upon Wnt/ β-catenin pathway - mediated tubule induction with a GSK-3 inhibitor or by initiation through the ureteric bud.

[Oncogene] By analyzing The Cancer Genome Atlas database, the leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) was found to be correlated with a poor prognosis of cervical cancer.

[Therapeutic Advances in Chronic Disease] Real-time qualitative PCR and Western blot analysis were conducted to determine expression of HGF, PTEN, and osteoblast differentiation-related genes in ovariectomy-induced osteoporosis mice and the isolated bone marrow MSCs.

[Scientific Reports] Researchers showed here that astrocyte elevated gene-1 (AEG-1) was overexpressed in glioma tissues and associated with a worse subtype and a poor prognosis.

[Cell Death & Disease] Scientists investigated the role of circular RNA (circRNAs) which shared the same pre-mRNA with Sp1 transcription factor (SP1) in colorectal cancer (CRC) cells and identified that hsa_circ_0026628, a circRNA that originated from SP1 pre-mRNA, was upregulated in CRC cells.

[Scientific Reports] Researchers established human and mouse hepatocellular carcinoma cells with exon 3 skipping of β-catenin, which promoted nuclear translocation and activated the Wnt/β-catenin signaling pathway, by using newly developed multiplex CRISPR/Cas9-based genome engineering system.