Hippo-Yap Signaling Controls Lineage Differentiation of Mouse Embryonic Stem Cells through Modulating the Formation of Super-Enhancers

Investigators found that knockout of Mst1 and Mst2, two key components of the Hippo signaling in mouse ESCs, resulted in a disruption of differentiation into mesendoderm lineage. They revealed a novel mechanism on how the Hippo-YAP signaling pathway dictated ESC lineage differentiation.