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Pulmonary Cell NewsThe authors showed that cardiomyocyte-specific deletion of Brd4 in adult mice leads to acute deterioration of cardiac contractile function with mutant animals demonstrating a transcriptomic signature enriched for decreased expression of genes critical for mitochondrial energy production.
[Circulation]
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Padmanabhan Arun, Alexanian Michael, Linares-Saldana Ricardo, González-Terán Bárbara, Andreoletti Gaia, Huang Yu, Connolly Andrew J., Kim Wonho, Hsu Austin, Duan Qiming, Winchester Sarah A. B., Felix Franco, Perez-Bermejo Juan A., Wang Qiaohong, Li Li, Shah Parisha P., Haldar Saptarsi M., Jain Rajan, & Srivastava Deepak. (n.d.). BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.120.047753 Cite
