A GATA4-Regulated Secretory Program Suppresses Tumors through Recruitment of Cytotoxic CD8 T Cells

Investigators found that GATA4 promoted non-cell autonomous tumor suppression in multiple model systems. Mechanistically, they showed that Gata4-dependent tumor suppression required cytotoxic CD8 T cells and partially required the secreted chemokine CCL2.
[Nature Communications]
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Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming

The conversion of fibroblasts into induced cardiomyocytes may regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. Scientists explored the leveraging of Hippo pathway intermediates to enhance induced cardiomyocyte generation.
[Journal of the American Heart Association]
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MLL1 Is Required for Maintenance of Intestinal Stem Cells

Loss of mixed lineage leukemia 1 (MLL1) was accompanied by loss of intestinal stem cells and a differentiation bias towards the secretory lineage with increased numbers and enlargement of goblet cells.
[PLoS Genetics]
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Positive Feedback Loop of lncRNA SNHG1/miR-16-5p/GATA4 in the Regulation of Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury

The authors explored the role and molecular mechanism of lncRNA small nucleolar RNA host gene 1 (SNHG1) in ischemic cardiomyocyte injury.
[Molecular Medicine Reports]
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Fibroblast Transition to an Endothelial “Trans” State Improves Cell Reprogramming Efficiency

Scientists explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells and fibroblasts were treated with Gata4, Mef2c, and Tbx5 to assess the cardio-differentiation potential of these cells.
[Scientific Reports]
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Effect of the Phenylpyrrole Fungicide Fludioxonil on Cell Proliferation and Cardiac Differentiation in Mouse Embryonic Stem Cells

The potential effect of fludioxonil on cardiac differentiation was evaluated in mouse ESCs. Exposure to fludioxonil resulted in reduced size of mouse embryoid bodies and induced increasing expression levels of the pluripotency markers Oct4, Sox2 and Nanog.
[Reproductive Toxicology]
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Direct Reprogramming as a Route to Cardiac Repair

In recent years, direct reprogramming of resident cardiac fibroblasts to induced cardiac-like myocytes has emerged as a promising therapeutic strategy to repurpose the fibrotic response of the injured heart toward a functional myocardium.
[Seminars in Cell & Developmental Biology]
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Patient-Specific iPSC-Derived Cardiomyocytes Reveal Abnormal Regulation of FGF16 in a Familial Atrial Septal Defect

The authors generated a patient-specific iPSC line from a family cohort carrying a hereditary atrial septal defect (ASD) mutation in GATA4 gene, as well as a hESC line carrying the isogenic T280M mutation using the CRISPR/Cas9 genome editing method. The GATA4-mutant iPSCs and ESCs were then differentiated into cardiomyocytes to model GATA4 mutation-associated ASD.
[Cardiovascular Research]
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Injectable Hydrogel for Co-Delivery of 5-Azacytidine in Zein Protein Nanoparticles with Stem Cells for Cardiac Function Restoration

Injectable alginate based microporous hydrogel were used to deliver 5-Azacytidine in zein protein nanoparticle with mesenchymal stem cells for attenuating adverse cardiac remodelling after myocardial infarction.
[International Journal of Pharmaceutics]
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Interactivity of Biochemical and Physical Stimuli during Epigenetic Conditioning and Cardiomyocytic Differentiation of Stem and Progenitor Cells Derived from Adult Hearts

Mixed populations of cardiosphere-derived stem and progenitor cells containing proliferative and cardiomyogenically committed cells were obtained from adult rat hearts.
[Integrative Biology]
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Epithelial Expression of Gata4 and Sox2 Regulates Specification of the Squamous–Columnar Junction via MAPK/ERK Signaling in Mice

By using mouse genetics, lineage tracing, and organoid culture, scientists examined the development of the squamous–columnar junction in the mouse stomach, and thus define the unique features of transitional epithelium.
[Nature Communications]
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