ERG1 Plays an Essential Role in Rat Cardiomyocyte Fate Decision by Mediating AKT Signaling

Using the rat embryonic stem cells model, investigators showed that ERG1 was crucial in cardiomyocyte lineage commitment via interactions with integrin β1.
[Stem Cells]
Wang, D., Liu, C., Liu, H., Meng, Y., Lin, F., Gu, Y., Wang, H., Shang, M., Tong, C., Sachinidis, A., Ying, Q., Li, L., & Peng, L. (n.d.). ERG1 Plays an Essential Role in Rat Cardiomyocyte Fate Decision by Mediating AKT Signaling. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3328 Cite
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The Epigenetic Regulator Mll1 Is Required for Wnt-Driven Intestinal Tumorigenesis and Cancer Stemness

Investigators identified the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5+ stem cells and human colon carcinomas with increased nuclear β-catenin.
[Nature Communications]
Grinat, J., Heuberger, J., Vidal, R. O., Goveas, N., Kosel, F., Berenguer-Llergo, A., Kranz, A., Wulf-Goldenberg, A., Behrens, D., Melcher, B., Sauer, S., Vieth, M., Batlle, E., Stewart, A. F., & Birchmeier, W. (2020). The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness. Nature Communications, 11(1), 6422. https://doi.org/10.1038/s41467-020-20222-z Cite
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Matrix Stiffness Regulates Myocardial Differentiation of Human Umbilical Cord Mesenchymal Stem Cells

Human umbilical cord-MSCs were cultured on polyacrylamide hydrogels with stiffnesses corresponding to Young’s modulus of 13-16kPa and 62-68kPa which mimic the stiffnesses of healthy heart tissue and fibrotic myocardium.
[Aging]
Aging | Matrix stiffness regulates myocardial differentiation of human umbilical cord mesenchymal stem cells - Full Text. (n.d.). Retrieved December 16, 2020, from https://www.aging-us.com/article/202244/text Cite
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An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development

Researchers describe a fully defined feeder-free protocol to generate early testis-like cells with the ability to be cultured as an organoid, from human induced pluripotent stem cells.
[Stem Cell Reports]
Knarston, I. M., Pachernegg, S., Robevska, G., Ghobrial, I., Er, P. X., Georges, E., Takasato, M., Combes, A. N., Jørgensen, A., Little, M. H., Sinclair, A. H., & Ayers, K. L. (2020). An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.10.009 Cite
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BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

The authors showed that cardiomyocyte-specific deletion of Brd4 in adult mice leads to acute deterioration of cardiac contractile function with mutant animals demonstrating a transcriptomic signature enriched for decreased expression of genes critical for mitochondrial energy production.
[Circulation]
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GATA6 Mutations in hiPSCs Inform Mechanisms for Maldevelopment of the Heart, Pancreas, and Diaphragm

To define molecular mechanisms for the damaging cardiac outflow tract defects caused by GATA6 variants, scientists studied transcriptional and epigenetic responses to GATA6 loss of function and missense variants during cardiomyocyte differentiation of isogenic human iPSCs.
[eLife]
Sharma, A., Wasson, L. K., Willcox, J. A., Morton, S. U., Gorham, J. M., DeLaughter, D. M., Neyazi, M., Schmid, M., Agarwal, R., Jang, M. Y., Toepfer, C. N., Ward, T., Kim, Y., Pereira, A. C., DePalma, S. R., Tai, A., Kim, S., Conner, D., Bernstein, D., … Seidman, C. E. (2020). GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm. ELife, 9, e53278. https://doi.org/10.7554/eLife.53278 Cite
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12-O-Tetradecanoylphorbol-13-Acetate Increases Cardiomyogenesis through PKC/ERK Signaling

Scientists showed that 12-O-tetradecanoylphorbol-13-acetate can be applied as a cardiomyogenesis-promoting factor for the differentiation of mouse embryonic stem cells in vitro.
[Scientific Reports]
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