Both glioblastoma stem cells, grown in classical 2D culture and in 3D-tumor organoids, formed functional tunneling nanotubes which allowed mitochondria transfer.
[Biochemical Journal]
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Pinto, G., Saenz de Santa Maria, I., Chastagner, P., Perthame, E., Delmas, C., Toulas, C., Moyal-Jonathan-Cohen, E., Brou, C., & Zurzolo, C. (n.d.). Patient-derived Glioblastoma Stem cells transfer mitochondria through Tunneling Nanotubes in Tumor Organoids. Biochemical Journal. https://doi.org/10.1042/BCJ20200710 Cite