Angiotensin II-Induced Muscle Atrophy via PPARγ Suppression Is Mediated by miR-29b

By
Justin.choi
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0
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Scientists identified peroxisome proliferator-activated receptor gamma (PPARγ) as a negative regulator of miR-29b, a microRNA that is able to promote multiple types of muscle atrophy. Suppression of miR-29b prevented AngII-induced muscle atrophy both in vitro and in vivo.
[Molecular Therapy-Nucleic Acids]
Li, J., Yang, T., Sha, Z., Tang, H., Hua, X., Wang, L., Wang, Z., Gao, Z., Sluijter, J. P., Rowe, G. C., Das, S., Yang, L., & Xiao, J. (2020). Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.12.015 Cite
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